What is Gastroparesis?
Gastroparesis, also called delayed gastric emptying, is a disorder that slows or stops the movement of food from the stomach to the small intestine. Normally, the muscles of the stomach, which are controlled by the vagus nerve, contract to break up food and move it through the gastrointestinal (GI) tract. Gastroparesis can occur when the vagus nerve is damaged by illness or injury and the stomach muscles stop working normally.
Causes of Gastroparesis
The cause of Gastroparesis for most people diagnosed with gastroparesis cannot be determined (idiopathic gastroparesis). Diabetes is the most common known cause of gastroparesis. High blood glucose levels can damage the vagus nerve. Other causes of gastroparesis include intestinal surgery and nervous system diseases such as Parkinson's disease or multiple sclerosis.
Symptoms of Gastroparesis
The most common symptoms of gastroparesis are chronic nausea, vomiting (especially of undigested food) and early satiety. Other symptoms may include palpitations, heartburn, abdominal pain, abdominal bloating, erratic blood glucose levels, lack of appetite, gastroesophageal reflux and spasms of the stomach wall. Morning nausea may also indicate gastroparesis.
Motilium Tablets – Product Information
Motilium Tablets manufactured by Johnson&Johnson are indicated for the short-term treatment in adults of symptoms associated with idiopathic or diabetic gastroparesis . They are also used to treat intractable nausea and vomiting from any cause.
In the case of diabetic gastroparesis, as soon as control of diabetes has been established by diet and/or insulin, an attempt should be made to discontinue Motilium therapy. The active pharmaceutical ingredient present in Motilium Tablets is Domperidone.
Motilium Tablets - Contraindications
Motilium is contraindicated in patients that have hypersensitivity to Domperidone or any inactive component of this medicine. It is also contraindicated in in those patients with a prolactin-releasing pituitary tumour (prolactinoma). The simultaneous administration of Motilium with oral ketoconazole, erythromycin, or other potent CYP3A4 inhibitors, which prolong the QTc interval such as fluconazole, voriconazole, clarithromycin, amiodarone, and telithromycin, is contraindicated.
Motilium Tablets - Dosage and Administration
Motilium should be taken 15-30 minutes before meals and, if necessary, before going to bed. The recommended adult dosage of Motilium for adults is one 10 mg tablet three to four times daily. If necessary this dose can be doubled after two weeks if an adequate therapeutic response is not attained.The maximum daily dose of Motilium is 80 mg.
Safety and efficacy of Motilium (domperidone) use beyond six months has not been established.
Motilium Tablets - Overdosage Symptoms and Treatment
Symptoms of Motilium overdosage may include disorientation, somnolence and extrapyramidal reactions.
A specific antidote to domperidone is not available.In the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Side Effects of Motilium Tablets
The side effects of Motilium Tablets include dry mouth and headache. The uncommon side effects include increased prolactin levels, nervousness, insomnia, dizziness, thirst, lethargy, irritability, diarrhoea, regurgitation, appetite disorder, nausea, heartburn, constipation, urticaria, pruritus, rash, Pollakiuria, dysuria, Muscle spasms, asthenia, Conjunctivitis, stomatitis, drug intolerance, liver function test abnormal and cholesterol. Rare side effects include extrapyramidal side effects, galactorrhoea, gynaecomastia, amenorrhoea and extremely rare adverse effects that may occur include anaphylactic reactions including anaphylactic shock; angioneurotic oedema, allergic reaction, agitation, convulsion, somnolence, Sudden Cardiac Death and Serious Ventricular Arrhythmias.
Motilium Tablets - More Details
For more details please read the prescription information or watch the presentation below:
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