Sirdalud Tablets for Relief of Painful Muscle Spasms | Tizanidine HCl

Sirdalud Tablets (Tizanidine Hydrochloride) - Product Information

Sirdalud manufactured by Novartis is a centrally acting alpha2-adrenergic agonist. The active ingredient present in Sirdalud is Tizanidine HCl (Tizanidine) which is a white to off-white, fine crystalline powder. Tizanidine HCl is odorless or with a faint characteristic odor. Tizanidine is slightly soluble in water and methanol. Sirdalud is a muscle relaxant that is used to help relax certain muscles in your body.
Sirdalud Tablets are composed of the active ingredient, tizanidine hydrochloride (2.29 mg equivalent to 2 mg tizanidine base and 4.58 mg equivalent to 4 mg tizanidine base), and the inactive ingredients.

Sirdalud Tablets Tablets (Tizanidine Hydrochloride) - Uses

Sirdalud relieves the painful muscle spasms related to the static and functional disorders of the spine or following certain surgeries such as herniated intervertebral disc or osteoarthritis of the hip. It is also used to treat spasticity due to neurological disorders such as multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy.

Sirdalud Tablets - Contraindications

Simultaneous use of Tizanidine with Fluvoxamine or with Ciprofloxacin, potent inhibitors of CYP1A2, is contraindicated. Sirdalud is also contraindicated in patients with a known hypersensitivity to Tizanidine or any inactive component present in the formulation as well as in individuals with significantly impaired hepatic function.

Sirdalud Tablets - Dosage

The recommended dosage of Sirdalud Tablets for various indications is given below:
Painful muscle spasms:
2 to 4 mg three times daily.
Spasticity due to neurological disorders:
The maximum initial recommended dosage is 6 mg/day in 3 divided doses. The dosage is then increased stepwise to achieve optimum therapeutic response (generally between 12 to 24 mg/day). The maximum daily dose is 36 mg which should not be exceeded.

Side Effects of Sirdalud Tablets

With low doses of Sirdalud tablets, such as those recommended for the relief of painful muscle spasms the reported side effects were somnolence, fatigue, asthenia, dizziness, dry mouth, nausea, gastrointestinal disorder, transaminase increase, increased spasm or tone, blood pressure decrease.
With the higher doses, as recommended for the treatment of spasticity, muscular weakness, insomnia, sleep disorder, hallucination, hypotension, bradycardia, hepatitis and hepatic failure have also been reported in addition to the side effects for lower doses.

Sirdalud Tablets - More Details

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Sirdalud Tablets for Relief of Painful Muscle Spasms