Thursday 25 September 2014

Treatment of Myasthenia Gravis, Paralytic Ileus & Postoperative Urinary Retention using Generic Mestinon

What is Myasthenia Gravis?

Myasthenia gravis is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatigability. An autoimmune disorder occurs when the body's immune system mistakenly attacks healthy tissue. In people who suffer from myasthemia gravis, the body produces antibodies that block the muscle cells from receiving messages (neurotransmitters) from the nerve cell.
The external symptoms of myasthenia gravis is fatigability. Muscles become progressively weaker during periods of activity and improve after periods of rest. Muscles that control eye and eyelid movement, facial expressions, chewing, talking, and swallowing are especially susceptible. The muscles that control breathing and neck and limb movements can also be affected. Often, the physical examination yields results within normal limits.

Generic Mestinon (Distinon Tablets) – Product Information

Generic Mestinon (Distinon Tablets, manufactured by Samarth Pharma) is used to treat muscle weakness in people with myasthenia gravis, and to combat the effects of curariform drug toxicity. It is also used to treat paralytic ileus, postoperative urinary retention and orthostatic hypotension.

Generic Mestinon (Distinon Tablets) - Contraindications

Generic Mestinon are contraindicated in patients that have a hypersensitivity to Pyridostigmine Bromide or any inactive component of this medication. They are also contraindicated in the following cases:
Generic Mestinon should not be given to patients with mechanical gastrointestinal or urinary obstruction.
Generic Mestinon should not be used in conjunction with depolarising muscle relaxants such as suxamethonium as neuromuscular blockade may be potentiated and prolonged apnoea may result.

Generic Mestinon (Distinon Tablets) - Dosage

The dosage of Generic Mestinon for various indications is given below:
Myasthenia Gravis
Adults: Doses of 30 to 120 mg by mouth are given at intervals throughout the day when maximum strength is needed (for example on rising and before meal times). The usual duration of action of a dose is three to four hours.
Other indications:
The usual dose is 1 to 4 tablets of 60 mg by mouth

Side Effects of Generic Mestinon

The common side effects of Generic Mestinon tablets are nausea and vomiting, increased salivation, diarrhoea and abdominal cramps.

Generic Mestinon (Distinon Tablets) - Warnings and Precautions

The precautions to be taken when undergoing thereapy with Generic Mestinon are:
Hypersensitivity reactions may occur in susceptible individuals.
Extreme caution is required when administering Generic Mestinon to patients with bronchial asthma.
Care should be taken in patients with bradycardia, recent coronary occlusion, hypotension, vagotonia, epilepsy or Parkinsonism.
There is no evidence to suggest that Generic Mestinon has any special effects in the elderly. However, elderly patients may be more susceptible to dysrhythmias than the younger adult.
Generic Mestinon is mainly excreted unchanged by the kidney, therefore lower doses may be required in patients with renal disease and treatment should be based on titration of drug dosage to effect.
Generic Mestinon should not be given during cyclopropane or halothane anaesthesia; however, it may be used after withdrawal of these agents.

Generic Mestinon Tablets) - More Details

For more details please read the Prescription Information or watch the presentation below:

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