What is osteoporosis?
Osteoporosis is a disease of bones which causes bones to become more porous, gradually making them weaker, more brittle and leads to an increased risk of fracture. Osteoporosis is common in postmenopausal women and also may occur in men. Osteoporosis often occurs in women several years after, the menopause, which occurs when the ovaries virtually stop producing the female hormone, oestrogen, or are removed (which may occur, for example, at the time of a hysterectomy). The earlier a woman reaches the menopause, the greater the risk of osteoporosis.
As many as half of all women and a quarter of men older than 50 will break a bone due to osteoporosis.
In osteoporosis, the bone mineral density (BMD) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered. Although Osteoporosis itself has no symptoms, its main consequence is the increased risk of bone fractures. Osteoporotic fractures occur in situations where healthy people would not normally break a bone; they are therefore regarded as fragility fractures.
What is Paget's Disease?
Paget's disease of bone is a disease that can result in enlarged and misshapen bones. In people with Paget's disease, there is excessive breakdown of bone tissue, and formation of new bone tissue causing the affected bone to weaken, resulting in pain, misshapen bones, fractures, and arthritis in the joints near the affected bones.
Paget's disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which usually affects all the bones in the body. It often involves bones of the arms, collarbones, leg, pelvis, spine, and skull.The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand.
Generic Fosamax (Osteofos Tablets) – Product Information
Generic Fosamax (Osteofos Tablets) is used to prevent osteoporosis in postmenopausal women, and to treat Paget's disease of the bone. Generic Fosamax is also used to treat or prevent osteoporosis in men, premenopausal women and postmenopausal women using oestrogen who are receiving corticosteroid medicines, such as prednisone and dexamethasone.
Generic Fosamax Tablets - Contraindications
Generic Fosamax (Osteofos Tablets) are contraindicated in patients that have a hypersensitivity to Alendronate Sodium tor any inactive component of this medication. They are also contraindicated in patients that have Hypocalcaemia or abnormalities of the oesophagus which delay oesophageal emptying such as stricture or achalasia.
Osteofos Tablets should not be administered to patients that are unable to stand or sit upright for at least 30 minutes.
Generic Fosamax (Osteofos Tablets) - Dosage
Generic Fosamax must be taken at least one half hour before the first food, beverage, or medication of the day with plain water only. To reduce the chances of oesophageal irritation, Generic Fosamax should only be swallowed upon arising for the day with a full glass of water and patients should not lie down for at least 30 minutes and until after their first food of the day. The recommended dosage of for various indications is given below:
Treatment of Osteoporosis in Postmenopausal Women and in Men :
The recommended dosage is one 70 mg tablet once weekly.
Prevention of Osteoporosis in Postmenopausal Women:
The recommended dosage is 5 mg once a day.
Treatment and Prevention of Glucocorticoid-Induced Osteoporosis in Men, Premenopausal Women and Postmenopausal Women Receiving Oestrogen :
The recommended dosage is 5 mg once a day.
Paget's Disease of Bone in men and women : The recommended treatment regimen is 40 mg once a day for six months.
Side Effects of Generic Fosamax Tablets
The following upper gastrointestinal side effects were reported in 1% or more of patients treated with Generic Fosamax 10 mg/day and at a greater incidence than in patients treated with placebo: abdominal pain, dyspepsia, oesophageal ulcer, dysphagia and abdominal distention. Rarely, rash and erythema have occurred. Additionally, the following side effects were also reported in 1% or more of patients treated with Generic Fosamax 10 mg/day and at a greater incidence than in patients treated with placebo: musculoskeletal (bone, muscle or joint) pain, constipation, diarrhoea, flatulence, and headache.
Generic Fosamax Tablets - More Details
For more details please watch the presentation below:
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