What is Acne?
Acne vulgaris (cystic acne or simply acne) is a human skin condition characterized by areas of skin with intense erythema, inflammation, seborrhea (scaly red skin), comedones (blackheads and whiteheads), papules (pinheads), pustules (pimples), nodules (large papules), cysts, and possibly scarring.
Acne affects mostly skin with the densest population of sebaceous follicles; these areas include the face, the upper part of the chest, and the back. Severe acne is inflammatory, but acne can also manifest in noninflammatory forms.
The lesions are caused by changes in pilosebaceous units, skin structures consisting of a hair follicle and its associated sebaceous gland, changes that require androgen stimulation.
Some of the large nodules were previously called "cysts" and the term nodulocystic has been used to describe severe cases of inflammatory acne. Oral antibacterials, were initially used as the first line therapy for severe nodular acne.
However due to concerns of antibacterial adverse effects, patient adherence, and antimicrobial resistance the search for
alternate therapies started and finally Isotretinoin, an oral retinoid was introduced in 1982.
Oral antibacterials are still used as an alternative for patients with severe acne who have a hypersensitivity towards oral retinoids, or for whom the use of retinoids is contraindicated.
Generic Accutane (Isotretinoin) – Product Information
Generic Accutane Capsules (Isotroin), an extremely powerful and potent acne-controlling medicine, is used to treat severe recalcitrant nodular acne that has failed other therapy. Nodules are inflammatory lesions with a diameter of 5 mm or greater. The nodules may become suppurative or hemorrhagic. "Severe," by definition, means "many" as opposed to "few or several" nodules.
A single course of therapy for 15 to 20 weeks has been shown to result in complete and prolonged remission of disease in many patients. If a second course of therapy is needed, it should not be initiated until at least 8 weeks after completion of the first course.
Isotretinoin is available as Roaccutane, Isotroin, Tretiva, Amnesteem, Claravis, and Sotret. Earlier it was available as Accutane in the US market.
Generic Accutane (Isotretinoin Capsules) - Contraindications
Generic Accutane Capsules are contraindicated in patients that have a hypersensitivity to Isotretinoin or any inactive component of this medication. They are also contraindicated in the following cases:
Generic Accutane should not be given to female patients that are pregnant.
Generic Accutane (Isotroin Capsules) - Dosage
The recommended adult Oral dosage of Generic Accutane (Isotroin Capsules) is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks.
Accutane should always be administered with a meal. Failure to take Accutane with food will significantly decrease absorption.
Side Effects of Generic Accutane (Isotroin Capsules)
The side effects reported in patients treated with Generic Accutane capsules are Anemia, Increased red blood cell sedimentation rate, Thrombocytopenia, Thrombocytosis, Neutropenia, Headache, Blepharitis, Conjunctivitis, Dry eyes, Eye irritation, Epistaxis, Nasal dryness, Nasopharyngitis, Increased transaminase, Cheilitis, Dermatitis, Dry skin, Localised exfoliation, Pruritus, Rash, Erythematous, Skin fragility, Arthralgia, Myalgia, Back pain, Increased triglycerides, Decreased HDL, Increased blood cholesterol, Increased blood glucose, Haematuria, and Proteinuria.
Generic Accutane Capsules - More Details
For more details please read the Prescription Information or watch the presentation below:
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